Malaria News

Anti-malarial activity and toxicity assessment of <it>Himatanthus articulatus</it>, a plant used to treat malaria in the Brazilian Amazon
Plasmodium falciparum has become resistant to some of the available drugs. Several plant species are used for the treatment of malaria, such as Himatanthus articulatus in parts of Brazil. The present paper reports the phyto-chemistry, the anti-plasmodial and anti-malarial activity, as well as the toxicity of H. articulatus. Ethanol and dichloromethane extracts were obtained from the powder of stem barks of H. articulatus and later fractionated and analysed. The anti-plasmodial activity was assessed against a chloroquine resistant strain P.
27/03/2015  from Malaria Journal     Read More      Permalink
We need a new political ethos that values science - The Drum (Australian Broadcasting Corporation)
Too often governments sideline science and allow vested interests to distort the system. We need a new version of politics that recognises that good science and democracy are mutually supportive.
27/03/2015  from ABC Health     Read More      Permalink
Researchers master gene editing technique in mosquito that transmits deadly diseases
Researchers have successfully harnessed a technique, CRISPR-Cas9 editing, to use in an important and understudied species: the mosquito, Aedes aegypti, which infects hundreds of millions of people annually with the deadly diseases chikungunya, yellow fever, and dengue fever.
26/03/2015 3:23:25 PM  from Science Daily     Read More      Permalink
Do frontline health care providers know enough about artemisinin&#8211;based combination therapy to rationally treat malaria? A cross-sectional survey in Gezira State, Sudan
In 2004, artemisinin-based combination therapy (ACT) was introduced in Sudan for the treatment of malaria. The role of health care providers working in first-level health care facilities is central for the effective implementation of this revised malaria treatment policy. However, information about their level of ACT knowledge is inadequate. This study sought to describe frontline health care providers’ knowledge about the formulations and dose regimens of nationally recommended ACT in Sudan. Overall, ACT knowledge among frontline health care providers is very poor.
26/03/2015  from Malaria Journal     Read More      Permalink
Studying the effect of chloroquine on sporozoite-induced protection and immune responses in <it>Plasmodium berghei</it> malaria
Sporozoite immunization of animals and humans under a chemo-prophylactic cover of chloroquine (CPS-CQ) efficiently induces sterile protection against malaria. In humans, CPS-CQ is strikingly more efficient than immunization with radiated attenuated sporozoites (RAS), raising the hypothesis that this might be partially due to CQ. Chloroquine, an established anti-malarial drug, is also well known for its immune modulating properties including improvement of cross-presentation. The aim of this study was to investigate whether co-administration of CQ during sporozoite immunization improves cellular responses and protective efficacy in Plasmodium berghei models. A number of experiments in selected complimentary P. berghei murine models in Balb/cByJ and C57BL/6j mice was performed.
26/03/2015  from Malaria Journal     Read More      Permalink
Prevalence of <it>Plasmodium falciparum</it> anti-malarial resistance-associated polymorphisms in <it>pfcrt</it>, <it>pfmdr1</it> and <it>pfnhe1</it> in Muheza, Tanzania, prior to introduction of artemisinin combination therapy
A report of the chloroquine and amodiaquine resistance pfcrt-SVMNT haplotype in Tanzania raises concern about high-level resistance to the artesunate-amodiaquine combination treatment widely employed in Africa. Mutations in the pfmdr1 multi-drug resistance gene may also be associated with resistance, and a highly polymorphic microsatellite (ms-4760) of the pfnhe1 gene involved in quinine susceptibility has not been surveyed in Tanzania. The pfcrt-CVIET chloroquine resistance haplotype dominated in the collection of P. falciparum samples from Muheza. The pfcrt-SVMNT haplotype, which threatens the efficacy of amodiaquine and was reported in the same time period from Korogwe, Tanzania, 40 Km from Muheza, was not detected.
25/03/2015  from Malaria Journal     Read More      Permalink
Splenic architecture disruption and parasite-induced splenocyte activation and anergy in <it>Plasmodium falciparum</it>-infected <it>Saimiri sciureus</it> monkeys
The understanding of the mechanisms of immunity in malaria is crucial for the rational development of interventions such as vaccines. During blood stage infection, the spleen is considered to play critical roles in both immunity and immunopathology of Plasmodium falciparum infections. Saimiri sciureus monkeys were inoculated with blood stages of P. falciparum (FUP strain) and spleens removed during acute disease (days 7 and 13 of infection) and during convalescence (15 days after start of chloroquine treatment). Cytokine (IFNγ, TNFα, IL2, IL6, IL10, and IL12) responses of splenocytes stimulated with P.
25/03/2015  from Malaria Journal     Read More      Permalink
Post-marketing surveillance of anti-malarial medicines used in Malawi
The growing concern over the extent of anti-malarial medicine resistance in sub-Saharan Africa, driven largely by administration of sub-therapeutic doses derived from falsified and substandard medicines necessitates regular monitoring of the quality of these medicines to avert any potential public health disaster. This study aimed at determining the active pharmaceutical ingredient (API) content of anti-malarial medicines available in Malawi with respect to the manufacturers’ label claim and pharmacopoeia specifications. Samples of anti-malarial medicines (112) collected from both licensed and unlicensed markets throughout Malawi were subjected to visual inspection of dosage form and packaging, and registration verification with the regulatory body.
25/03/2015  from Malaria Journal     Read More      Permalink
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