Malaria News

New approaches to combating malaria
World Malaria Day reminds us of the life threatening disease, that is both preventable and curable.
25/04/2014  from ABC Health     Read More      Permalink
World Malaria Day: Hopes 'positive deviance' scheme in Myanmar can help control, prevent disease - Australia Network News (Australian Broadcasting Corporation)
Malaria remains one of the world's biggest health challenges, but a new pilot scheme in Myanmar is hoping to turn the tide by promoting positive knowledge, attitudes and behaviour.
25/04/2014  from ABC Health     Read More      Permalink
Positive Deviance
Malaria Consortium is implementing an innovative project that will pilot positive deviance in six villages of Kyunsu Township, in Kadan Kyun -- the largest island in the Mergui Archipelago and a high-risk malaria area of Thanintharyi region in
25/04/2014  from ABC Health     Read More      Permalink
APMEN celebrates World Malaria Day 2014 with a commitment to a malaria-free Asia Pacific region
The Country Partners of the Asia Pacific Malaria Elimination Network are committed to defeating malaria in the region and have co-signed a Declaration of Commitment ahead of World Malaria Day 2014 to highlight their elimination goals. APMEN is composed of 15 countries in the Asia Pacific region (Bhutan, Cambodia, China, Democratic People's Republic of Korea, Indonesia, Lao People's Democratic Republic, Malaysia, Nepal, Philippines, Republic of Korea, the Solomon Islands, Sri Lanka, Thailand, Vanuatu and Vietnam) who currently share a common goal to eliminate malaria, either at the national or sub-national level. The 'Manila Declaration' was signed by the National Malaria Program Managers from 14 of the 15 Country Partners that were present at APMEN VI, the sixth annual meeting of the Network held in Manila, Philippines, March 11 -13, 2014. The Declaration re-affirms the commitment of countries to two APMEN goals: 1) the long-term goal is to eliminate malaria in the Asia Pacific region, and 2) for half the countries in the Asia Pacific region with malaria today to achieve their elimination targets by 2025. Click here to see the national and sub-national elimination targets of the 15 APMEN Country Partners. APMEN supports our Partner Institution, the Roll Back Malaria (RBM) Partnership, and the theme of "Invest in the future: Defeat malaria" to call attention to the need to reach the 2015 Millennium Development Goals and pursue a malaria-free future for the Asia Pacific.
24/04/2014  by Rebekah McBride     Read More      Permalink
Researchers hope for new role for choloroquine in fight against malaria - Australia Network News (Australian Broadcasting Corporation)
Researchers are hoping the medication which once led the fight against malaria can once again fight against the mosquito-borne disease.
21/04/2014  from ABC Health     Read More      Permalink
Timelier notification and action with mobile phones-towards malaria elimination in South Africa
Surveillance with timely follow-up of diagnosed cases is a key component of the malaria elimination strategy in South Africa. The strategy requires each malaria case to be reported within 24 hours, and a case should be followed up within 48 hours. However, reporting delays are common in rural parts of the country. A technical framework was implemented and for eight months a nurse was hired to use a smartphone to report malaria cases to the provincial malaria control programme, from selected primary health care clinics in a rural, malaria-endemic area in South Africa. In addition, a short text message (SMS) notification was sent to the local malaria case investigator for each positive case.
21/04/2014  from Malaria Journal     Read More      Permalink
Biochemical and functional characterization of Plasmodium falciparum GTP cyclohydrolase I
Antifolates are currently in clinical use for malaria preventive therapy and treatment. The drugs kill the parasites by targeting the enzymes in the de novo folate pathway. The use of antifolates has now been limited by the spread of drug-resistant mutations. GTP cyclohydrolase I (GCH1) is the first and the rate-limiting enzyme in the folate pathway. The amplification of the gch1 gene found in certain Plasmodium falciparum isolates can cause antifolate resistance and influence the course of antifolate resistance evolution. These findings showed the importance of P. falciparum GCH1 in drug resistance intervention. However, little is known about P.
19/04/2014  from Malaria Journal     Read More      Permalink
Targeting NAD+ Metabolism in the Human Malaria Parasite Plasmodium falciparum
by Jessica K. O'Hara, Lewis J. Kerwin, Simon A. Cobbold, Jonathan Tai, Thomas A. Bedell, Paul J. Reider, Manuel Llinás Nicotinamide adenine dinucleotide (NAD+) is an essential metabolite utilized as a redox cofactor and enzyme substrate in numerous cellular processes. Elevated NAD+ levels have been observed in red blood cells infected with the malaria parasite Plasmodium falciparum, but little is known regarding how the parasite generates NAD+. Here, we employed a mass spectrometry-based metabolomic approach to confirm that P. falciparum lacks the ability to synthesize NAD+ de novo and is reliant on the uptake of exogenous niacin.
18/04/2014  from PLoS     Read More      Permalink
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