Malaria News

A critical review of traditional medicine and traditional healer use for malaria and among people in malaria-endemic areas: contemporary research in low to middle-income Asia-Pacific countries
Malaria is a leading health threat for low to middle-income countries and around 1.8 billion people in the Southeast Asian region and 870 million people in the Western Pacific region remain at risk of contracting malaria. Traditional medicine/traditional healer (TM/TH) use is prominent amongst populations in low- to middle-income countries and constitutes an important issue influencing and potentially challenging effective, safe and coordinated prevention and treatment strategies around malaria. This paper presents the first critical review of literature on the use of TM/TH for malaria prevention and treatment in low- to middle-income countries in the Asia-Pacific region. This review has provided crucial insights into the prevalence and profile of TM/TH use for malaria.
1/03/2015  from Malaria Journal     Read More      Permalink
Frequency and correlates of malaria over-treatment in areas of differing malaria transmission: a cross-sectional study in rural Western Kenya
In 2010, the World Health Organization shifted its malaria guidelines from recommending the empiric treatment of all febrile children to treating only those with laboratory-confirmed malaria. This study evaluated the frequency and predictors of malaria over-treatment among febrile malaria-negative children in Kenya. Between 2012 and 2013, 1,362 children presenting consecutively with temperature ≥37.5°C to Kisii and Homa Bay hospitals were enrolled in a cross-sectional study evaluating causes of fever. Children were screened for malaria using smear microscopy and rapid diagnostic tests and managed according to standard of care at the hospitals.
1/03/2015  from Malaria Journal     Read More      Permalink
Revealing the Sequence and Resulting Cellular Morphology of Receptor-Ligand Interactions during Plasmodium falciparum Invasion of Erythrocytes
by Greta E. Weiss, Paul R. Gilson, Tana Taechalertpaisarn, Wai-Hong Tham, Nienke W. M. de Jong, Katherine L. Harvey, Freya J. I. Fowkes, Paul N. Barlow, Julian C. Rayner, Gavin J. Wright, Alan F. Cowman, Brendan S. Crabb During blood stage Plasmodium falciparum infection, merozoites invade uninfected erythrocytes via a complex, multistep process involving a series of distinct receptor-ligand binding events. Understanding each element in this process increases the potential to block the parasite's life cycle via drugs or vaccines.
27/02/2015  from PLoS     Read More      Permalink
Malaria transmission linked to mosquitoes' sexual biology
Sexual biology may be the key to uncovering why Anopheles mosquitoes are unique in their ability to transmit malaria to humans, according to researchers. "Our study is the first to reveal the evolutionary dynamics between the sexes that are likely responsible for shaping the ability of Anopheles mosquitoes to transmit malaria to humans," said the study's senior author.
26/02/2015 3:46:01 PM  from Science Daily     Read More      Permalink
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26/02/2015  from New Scientist     Read More      Permalink
Distribution of Plasmodium falciparum gametocytes and malaria-attributable fraction of fever episodes along an altitudinal transect in Western Cameroon
Highland areas are hypoendemic zones of malaria and are therefore prone to epidemics, due to lack of protective immunity. So far, Cameroon has not succeeded in implementing a convenient and effective method to detect, prevent and forecast malaria epidemic in these peculiar zones. This monitoring and evaluation study aims to assess the operational feasibility of using the human malaria infectious reservoir (HMIR) and the malaria-attributable fraction of fever episodes (MAFE) as indicators, in designing a malaria epidemic early warning system (MEWS). Longitudinal parasitological surveys were conducted in sentinel health centres installed in three localities, located along an altitudinal transect in Western Cameroon: Santchou (750 m), Dschang (1,400 m) and Djuttitsa (1,965 m).
26/02/2015  from Malaria Journal     Read More      Permalink
Scientists develop novel method to suppress malaria parasite's virulence genes, break the code of its immune evasion
Up to one million people, mostly pregnant woman and young children, are killed each year by the Plasmodium falciparum parasite, which causes the most devastating form of human malaria. Now, researchers have revealed the genetic trickery this deadly parasite deploys to escape attack by the human immune system.
25/02/2015 8:27:41 AM  from Science Daily     Read More      Permalink
Submicroscopic and asymptomatic Plasmodium falciparum and Plasmodium vivax infections are common in western Thailand - molecular and serological evidence
Malaria is a public health problem in parts of Thailand, where Plasmodium falciparum and Plasmodium vivax are the main causes of infection. In the northwestern border province of Tak parasite prevalence is now estimated to be less than 1% by microscopy. Nonetheless, microscopy is insensitive at low-level parasitaemia. The objective of this study was to assess the current epidemiology of falciparum and vivax malaria in Tak using molecular methods to detect exposure to and infection with parasites; in particular, the prevalence of asymptomatic infections and infections with submicroscopic parasite levels. These findings suggest that parasite prevalence is higher than currently estimated by local authorities based on the standard light microscopy.
25/02/2015  from Malaria Journal     Read More      Permalink
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