Malaria News

Mining geographic variations of Plasmodium vivax for active surveillance: a case study in China
Geographic variations of an infectious disease characterize the spatial differentiation of disease incidences caused by various impact factors, such as environmental, demographic, and socioeconomic factors. Some factors may directly determine the force of infection of the disease (namely, explicit factors), while many other factors may indirectly affect the number of disease incidences via certain unmeasurable processes (namely, implicit factors). In this study, the impact of heterogeneous factors on geographic variations of Plasmodium vivax incidences is systematically investigate in Tengchong, Yunnan province, China. A space‐time model that resembles a P.
27/05/2015  from Malaria Journal     Read More      Permalink
Malaria preventive therapy in pregnancy and its potential impact on immunity to malaria in an area of declining transmission
Regular anti-malarial therapy in pregnancy, a pillar of malaria control, may affect malaria immunity, with therapeutic implications in regions of reducing transmission. Different preventive anti-malarial chemotherapy regimens used during pregnancy had limited impact on malarial-immunity in a low-transmission region of Papua New Guinea.Trial registrationsNCT01136850.
26/05/2015  from Malaria Journal     Read More      Permalink
Nowhere to hide: interrogating different metabolic parameters of <it>Plasmodium falciparum</it> gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination
The discovery of malaria transmission-blocking compounds is seen as key to malaria elimination strategies and gametocyte-screening platforms are critical filters to identify active molecules. However, unlike asexual parasite assays measuring parasite proliferation, greater variability in end-point readout exists between different gametocytocidal assays. This is compounded by difficulties in routinely producing viable, functional and stage-specific gametocyte populations. Here, a parallel evaluation of four assay platforms on the same gametocyte populations was performed for the first time.
22/05/2015  from Malaria Journal     Read More      Permalink
Identification of sibling species status of <it>Anopheles culicifacies</it> breeding in polluted water bodies in Trincomalee district of Sri Lanka
Anopheles culicifacies s.l., the major vector of malaria in Sri Lanka, is known to breed in clean and clear water. However, recent findings have confirmed breeding from waste water bodies in urban and semi-urban areas. No study has been conducted to identify whether it is vector or non-vector siblings. The objective of the study was to identify the sibling species status of An. culicifacies s.l. Anopheles culicifacies s.l. adult samples (reared from larvae) were obtained from the Padavisiripura Entomological team attached to Tropical and Environmental Diseases and Health Associates (TEDHA) Malaria Elimination Programme in Trincomalee District. The collected mosquito specimens were processed for the extraction of genomic DNA individually.
22/05/2015  from Malaria Journal     Read More      Permalink
Epstein-Barr virus co-infection may boost malaria mortality in childhood
Malaria researchers are calling attention to a trouble-maker whose effects may be underappreciated: Epstein-Barr virus (EBV). Their experiments with mice show that co-infection with a virus closely related to EBV can make a survivable malaria parasite infection lethal.
21/05/2015 2:40:30 PM  from Science Daily     Read More      Permalink
Can a viral co-infection impair immunity against Plasmodium and turn malaria lethal?
It is known that infections with certain viruses can weaken the immune response to another pathogen. A new study reports provocative findings in mice that infection with the mouse equivalent of Epstein-Barr virus can turn infections with certain parasites that cause malaria in mice (which are normally quickly suppressed by the immune system) into a lethal disease.
21/05/2015 2:39:22 PM  from Science Daily     Read More      Permalink
Mosquito sex-determining gene could help fight dengue fever
A gene responsible for sex determination in mosquitoes that can transmit yellow fever, dengue, and chikungunya viruses has been identified by researchers. Only female mosquitoes bite because they need blood for developing eggs, and researchers believe that a higher ratio of males could reduce disease transmission.
21/05/2015 2:38:15 PM  from Science Daily     Read More      Permalink
Gammaherpesvirus Co-infection with Malaria Suppresses Anti-parasitic Humoral Immunity
by Caline G. Matar, Neil R. Anthony, Brigid M. O'Flaherty, Nathan T. Jacobs, Lalita Priyamvada, Christian R. Engwerda, Samuel H. Speck, Tracey J. Lamb Immunity to non-cerebral severe malaria is estimated to occur within 1-2 infections in areas of endemic transmission for Plasmodium falciparum. Yet, nearly 20% of infected children die annually as a result of severe malaria. Multiple risk factors are postulated to exacerbate malarial disease, one being co-infections with other pathogens. Children living in Sub-Saharan Africa are seropositive for Epstein Barr Virus (EBV) by the age of 6 months. This timing overlaps with the waning of protective maternal antibodies and susceptibility to primary Plasmodium infection.
21/05/2015  from PLoS     Read More      Permalink
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