Malaria News

Ebola outbreak shuts down malaria-control efforts
Nature 514, 15-16 doi:10.1038/514015a
2/10/2014 3:00:27 PM  from Nature     Read More      Permalink
Biopiracy ban stirs red-tape fears
Nature 514, 14-15 doi:10.1038/514014a
2/10/2014 3:00:27 PM  from Nature     Read More      Permalink
Changing epidemiology of malaria in Sabah, Malaysia: increasing incidence of Plasmodium knowlesi
While Malaysia has had great success in controlling Plasmodium falciparum and Plasmodium vivax, notifications of Plasmodium malariae and the microscopically near-identical Plasmodium knowlesi increased substantially over the past decade. However, whether this represents microscopic misdiagnosis or increased recognition of P. knowlesi has remained uncertain. To describe the changing epidemiology of malaria in Sabah, in particular the increasing incidence of P. knowlesi, a retrospective descriptive study was undertaken involving a review of Department of Health malaria notification data from 2012-2013, extending a previous review of these data from 1992-2011.
2/10/2014  from Malaria Journal     Read More      Permalink
A fast, non-invasive, quantitative staining protocol provides insights in Plasmodium falciparum gamete egress and in the role of osmiophilic bodies
Ability of Plasmodium falciparum gametocytes to become extracellular during gametogenesis in the mosquito midgut is a key step of the parasite life cycle. Reliable and quantitative measurement of the efficiency of gamete egress is currently constrained by the fact that this phenomenon is usually observed and quantified in vitro either by live microscopy, by statistically limited ultrastructural analysis or by surface antibody-based protocols which can interfere with this fast and complex cellular process. A protocol was developed based on fluorescent wheat germ agglutinin (WGA) surface staining of erythrocytes containing mature P. falciparum gametocytes.
1/10/2014  from Malaria Journal     Read More      Permalink
Children never forget warring parents - The Drum (Australian Broadcasting Corporation)
Children caught in the rows between mothers and war-damaged fathers never forget those years, as I can attest. Adults might think the child can cope, but the child cannot.
1/10/2014  from ABC Health     Read More      Permalink
Humanized HLA-DR4.RagKO.IL2RgammacKO.NOD (DRAG) mice sustain the complex vertebrate life cycle of Plasmodium falciparum malaria
Malaria is a deadly infectious disease affecting millions of people in tropical and sub-tropical countries. Among the five species of Plasmodium parasites that infect humans, Plasmodium falciparum accounts for the highest morbidity and mortality associated with malaria. Since humans are the only natural hosts for P. falciparum, the lack of convenient animal models has hindered the understanding of disease pathogenesis and prompted the need of testing anti-malarial drugs and vaccines directly in human trials. Humanized mice hosting human cells represent new pre-clinical models for infectious diseases that affect only humans. In this study, the ability of human-immune-system humanized HLA-DR4.RagKO.IL2RgammacKO.NOD (DRAG) mice to sustain infection with P. falciparum was explored.
30/09/2014  from Malaria Journal     Read More      Permalink
Low genetic diversity in the locus encoding the Plasmodium vivax P41 protein in Colombia's parasite population
The development of malaria vaccine has been hindered by the allele-specific responses produced by some parasite antigens' high genetic diversity. Such antigen genetic diversity must thus be evaluated when designing a completely effective vaccine. Plasmodium falciparum P12, P38 and P41 proteins have red blood cell binding regions in the s48/45 domains and are located on merozoite surface, P41 forming a heteroduplex with P12. These three genes have been identified in Plasmodium vivax and share similar characteristics with their orthologues in Plasmodium falciparum. Plasmodium vivax pv12 and pv38 have low genetic diversity but pv41 polymorphism has not been described. The present study was aimed at evaluating the P. vivax p41 (pv41) gene's polymorphism.
30/09/2014  from Malaria Journal     Read More      Permalink
Spatial clustering and risk factors of malaria infections in Ratanakiri Province, Cambodia
Malaria incidence worldwide has steadily declined over the past decades. Consequently, increasingly more countries will proceed from control to elimination. The malaria distribution in low incidence settings appears patchy, and local transmission hotspots are a continuous source of infection. In this study, species-specific clusters and associated risk factors were identified based on malaria prevalence data collected in the north-east of Cambodia. In addition, Plasmodium falciparum genetic diversity, population structure and gene flows were studied.MethodIn 2012, blood samples from 5793 randomly selected individuals living in 117 villages were collected from Ratanakiri province, Cambodia.
30/09/2014  from Malaria Journal     Read More      Permalink
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