Malaria News

Access to artemisinin-based combination therapy (ACT) and quinine in malaria holoendemic regions of western Kenya
Artemisinin-based combination therapy (ACT) has been adopted as the most effective treatment against malaria in many endemic countries like Kenya while quinine has remained the second line. The objective of the current study was to assess access to Kenya's policy recommended anti-malarials, ACT and quinine in the public, private and not-for-profit drug outlets in western Kenya. There is low availability of subsidized ACT (AL) and higher frequency of stock-outs in government facilities, while private sector sells AL at higher prices, thus making it less affordable to many households.
28/07/2014  from Malaria Journal     Read More      Permalink
Reduced prevalence of placental malaria in primiparae with blood group O
Blood group O protects African children against severe malaria and has reached high prevalence in malarious regions. However, its role in malaria in pregnancy is ambiguous. In 839 delivering Ghanaian women, associations of ABO blood groups with Plasmodium falciparum infection were examined. Plasmodium falciparum infection was diagnosed in placental blood samples by microscopy and PCR assays. Present or past infection was defined as the detection of parasitaemia or haemozoin by microscopy, or a positive PCR result. Blood groups were inferred from genotyping rs8176719 (indicating the O allele) and rs8176746/rs8176747 (distinguishing the B allele from the A allele). The majority of women had blood group O (55.4%); present or past P. falciparum infection was seen in 62.3% of all women.
28/07/2014  from Malaria Journal     Read More      Permalink
Measurement of parasitological data by quantitative real-time PCR from controlled human malaria infection trials at the Walter Reed Army Institute of Research
The use of quantitative real-time PCR (qPCR) has allowed for precise quantification of parasites in the prepatent period and greatly improved the reproducibility and statistical power of controlled human malaria infection (CHMI) trials. Parasitological data presented here are from non-immunized, control-challenged subjects who participated in two CHMI trials conducted at the Walter Reed Army Institute of Research (WRAIR). Smear positive is an endpoint which antimalarial rescue is imperative whereas early detection of parasitological data by qPCR can allow for better anticipation of the endpoint. This would allow for early treatment to reduce clinical illness and risk for study participants.
28/07/2014  from Malaria Journal     Read More      Permalink
"You're losing your Ghanaianess": understanding malaria decision-making among Africans visiting friends and relatives in the UK
In the UK, the majority of imported malaria infections occur in the London area among UK residents of African origin who travel to Africa visiting friends and relatives (VFRs). Effective malaria prevention measures are available but there is little understanding of the factors that enhance and constrain their use among VFRs. Semi-structured interviews were undertaken with Africans resident in London who visited friends and relatives in Nigeria and Ghana (n = 20) and with African VFRs recently treated for malaria (n = 6). Data collection took place between December 2007 and February 2011. Information on migration patterns and travel of respondents was collected and the data were analysed using a framework analysis approach. Knowledge of the link between mosquitoes and malaria was high.
27/07/2014  from Malaria Journal     Read More      Permalink
The challenge of artemisinin resistance can only be met by eliminating Plasmodium falciparum malaria across the Greater Mekong subregion
Artemisinin-based combinations are currently the most effective anti-malarials and, in addition to vector control, have led to significant declines in malaria morbidity and mortality. However, foci of artemisinin drug resistance have been identified in the Greater Mekong subregion (GMS) of the Asia Pacific, threatening the major gains made in malaria control and potentially creating a parasite pool that is more difficult to treat and eliminate. Efforts are underway to halt the spread of artemisinin resistance, including coordination of activities and funding, and identification of areas of suspected artemisinin resistance, now using a newly identified molecular marker.
27/07/2014  from Malaria Journal     Read More      Permalink
Making progress, but a long way to go: battling stigma against HIV AIDS in China - Australia Network News (Australian Broadcasting Corporation)
An NGO in a Chinese coastal city braves a public backlash to allow a space for HIV testing.
25/07/2014  from ABC Health     Read More      Permalink
Festival shows the promises and perils of open data
Governments and big businesses want information to be free, but how will it work? A Berlin festival last week cast a friendly but critical eye over the idea
25/07/2014  from New Scientist     Read More      Permalink
Correction: Malaria Parasite Infection Compromises Control of Concurrent Systemic Non-typhoidal Salmonella Infection via IL-10-Mediated Alteration of Myeloid Cell Function
by The PLOS Pathogens Staff
25/07/2014  from PLoS     Read More      Permalink
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